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KMID : 1161520080120040203
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Animal Cells and Systems
2008 Volume.12 No. 4 p.203 ~ p.209
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Neuroprotective effects of berberine in neurodegeneration model rats induced by ibotenic acid
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Lim Jung-Su
Kim Hyo-Sup
Choi Yoon-Seok
Kwon Hyock-Man
Shin Ki-Soon
Joung In-Sil
Shin Mi-Jung
Kwon Yun-Hee Kim
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Abstract
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Berberine, an isoquinoline alkaloid found in Coptidis Rhizoma (goldenthread) extract, has multiple pharmacological effects such as anti?inflammatory, antimicrobial and anti?ischemic effects. In the present study, we examined the effects of berberine on neuronal survival and differentiation in a hippocampal precursor cell line and in the memory deficient rat model. Berberine increased in a dose dependent manner the survival of hippocampal precursor cells as well as differentiated cells. In addition, berberine promoted neuronal differentiation of hippocampal precursor cells. In the memory deficient rat model induced by stereotaxic injection of ibotenic acid into entorhinal cortex (Ibo model), hippocampal cells were increased about 2.7 fold in the pyramidal layer of CA1 region and about 2 fold in the dentate gyrus by administration of berberine after 2 weeks of ibotenic acid injection. Furthermore, neuronal cells immunoreactive to calbindin were increased in the hippocampus and entorhinal cortex area by administration of berberine. Taken together, these results suggest that berberine has neuroprotective effect in the Ibo model rat brain by promoting the neuronal survival and differentiation.
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KEYWORD
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berberine, Alzheimer’s disease, Ibo model, neural precursor cell, neuronal survival, neuronal differentiation, regeneration
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